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Updated: Jun 22, 2026

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

Published on: May 9, 2012

Neurogenic muscle hypertrophy.

Isabelle Charlot-Lambrecht¹, Pascal Brochot, Hervé Noblet

¹Service de Rhumatologie, CHU Reims, 45 rue Cognacq Jay, 51 092 Reims cedex, France. charlot_isabelle@yahoo.fr

Joint Bone Spine

|June 2, 2009

Summary

A rare case of neurogenic muscle hypertrophy in the calf was observed 6 years after S1 sciatica. This condition, potentially linked to slow denervation and specific muscle activity, is not fully understood.

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Area of Science:

Neurology
Muscle Physiology
Radiology

Background:

Neurogenic muscle hypertrophy is a rare condition.
It is typically observed in middle-aged men with a history of S1 radiculopathy.
The soleus muscle is the most commonly affected site.

Observation:

A 48-year-old man presented with left calf hypertrophy 6 years post-S1 sciatica from a herniated disk.
Magnetic resonance imaging confirmed muscle hypertrophy.
Electromyography revealed left S1 radiculopathy with abnormal spontaneous muscle activity.

Findings:

The case highlights neurogenic muscle hypertrophy as a potential long-term consequence of S1 radiculopathy.
The pathophysiology may involve Type I fiber hypertrophy due to repetitive nerve discharges.
The condition is more common with slow, gradual denervation.

Implications:

This case expands the understanding of neurogenic muscle hypertrophy.
Further research is needed to elucidate the pathophysiology and natural history of this rare condition.
Clinicians should consider neurogenic muscle hypertrophy in patients with unexplained muscle enlargement following nerve injury.