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Related Experiment Video

Updated: Jun 22, 2026

Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization
06:36

Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization

Published on: July 17, 2014

Thyroid gland development and function in the zebrafish model.

P Porazzi1, D Calebiro, F Benato

  • 1Dipartimento di Scienze Mediche, Università degli Studi di Milano & Lab of Experimental Endocrinology, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano, Milan, Italy. patrizia.porazzi@unimi.it

Molecular and Cellular Endocrinology
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

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Zebrafish thyroid development, originating from pharyngeal endoderm, shares conserved genes with mammals. This review covers zebrafish thyroid gland development, thyroid hormones, and endocrine disruptors.

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Comparative Biology

Background:

  • The mouse model closely recapitulates human thyroid development.
  • Zebrafish thyroid tissue arises from pharyngeal endoderm, with conserved developmental genes.
  • Zebrafish embryos offer advantages for in vivo imaging and genetic studies.

Purpose of the Study:

  • To review current knowledge of zebrafish thyroid gland origin and differentiation.
  • To discuss the role of thyroid hormones in zebrafish.
  • To explore aspects related to endocrine disruptors in zebrafish.

Main Methods:

  • Literature review of zebrafish thyroid development.
  • Comparative analysis of gene conservation between zebrafish and mammals.
  • Discussion of zebrafish as a model organism for endocrine research.

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Last Updated: Jun 22, 2026

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06:36

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Published on: July 17, 2014

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis
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Main Results:

  • Zebrafish thyroid development involves conserved genetic pathways.
  • Thyroid hormones play crucial roles in zebrafish development and physiology.
  • Zebrafish are susceptible to endocrine disruptors.

Conclusions:

  • Zebrafish provide a valuable model for studying thyroid development and endocrine disruption.
  • Understanding conserved mechanisms aids in comparative endocrinology.
  • Further research in zebrafish can inform human health regarding thyroid function and environmental factors.