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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

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Updated: Jun 22, 2026

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging
10:57

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging

Published on: December 16, 2014

Leydig cells: From stem cells to aging.

Haolin Chen1, Ren-Shan Ge, Barry R Zirkin

  • 1Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. hchen@jhsph.edu

Molecular and Cellular Endocrinology
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Leydig cell development involves four stages, from stem cells to adult cells that produce testosterone. Aging reduces Leydig cell testosterone production, impacting male health.

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Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging
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Published on: December 16, 2014

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Cell Biology

Background:

  • Leydig cells are crucial for testosterone production in the testes.
  • Adult Leydig cells develop from undifferentiated stem cells in the neonatal testis.
  • Four distinct developmental stages of Leydig cells have been identified.

Purpose of the Study:

  • To review Leydig cell development from stem cells to mature, testosterone-producing cells.
  • To discuss the aging process of Leydig cells and its impact on testosterone synthesis.
  • To explore the molecular mechanisms underlying age-related decline in testosterone production.

Main Methods:

  • This review synthesizes existing research on Leydig cell development and aging.
  • It examines the characteristics of each Leydig cell developmental stage: stem, progenitor, immature, and adult.
  • The review discusses findings from studies, including those using the Brown Norway rat model for male reproductive aging.

Main Results:

  • Leydig cell development progresses through four distinct stages, each with unique characteristics and functions.
  • Aging is associated with a decline in serum testosterone levels in men.
  • In aged Brown Norway rats, Leydig cells show a reduced capacity for testosterone production in response to luteinizing hormone (LH) stimulation.

Conclusions:

  • Understanding Leydig cell development is key to understanding male reproductive function.
  • Age-related decline in testosterone synthesis is linked to impaired Leydig cell function.
  • Further research into the molecular mechanisms of Leydig cell aging may reveal therapeutic targets.