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A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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Replication studies based on findings from a genome-wide DNA microsatellite screen in diabetic nephropathy

R J Martin, A P Maxwell, C C Patterson

    Diabetes & Metabolism
    |June 2, 2009
    PubMed
    Abstract

    No abstract available in PubMed .

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    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...