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Updated: Jun 22, 2026

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
Published on: June 7, 2018
Modafinil reinstates a cocaine conditioned place preference following extinction in rats
Rick E Bernardi1, Jason R Lewis, K Matthew Lattal
1Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. bernardi@ohsu.edu
Abstract:
The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.
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