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Glucocorticoid resistance in inflammatory diseases
1National Heart and Lung Institute, Imperial College, London, UK. p.j.barnes@imperial.ac.uk
Lancet (London, England)
|June 2, 2009
Summary
Glucocorticoid resistance hinders treatment for inflammatory diseases. Strategies focus on reversing resistance by targeting molecular mechanisms like MAP kinase pathways and HDAC2 expression.
Area of Science:
- Immunology
- Pharmacology
- Molecular Biology
Background:
- Glucocorticoid resistance is a significant challenge in treating inflammatory conditions such as COPD, asthma, and rheumatoid arthritis.
- Key molecular mechanisms driving glucocorticoid resistance include MAP kinase activation, AP-1 activity, reduced HDAC2 expression, MIF, and P-glycoprotein efflux.
Purpose of the Study:
- To review the molecular mechanisms underlying glucocorticoid resistance.
- To explore therapeutic strategies for overcoming glucocorticoid resistance, including alternative treatments and methods to reverse resistance.
Main Methods:
- Literature review of molecular mechanisms of glucocorticoid resistance.
- Analysis of current and novel therapeutic approaches for glucocorticoid-resistant inflammatory diseases.
Main Results:
- Identified multiple molecular pathways contributing to glucocorticoid resistance.
- Highlighted alternative anti-inflammatory treatments and strategies to reverse resistance by targeting these pathways.
Conclusions:
- Targeting specific molecular mechanisms offers a promising approach to reverse glucocorticoid resistance.
- Further research into novel therapies is crucial for managing inflammatory diseases with glucocorticoid insensitivity.
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