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Non-T-cell lymphoblastic lymphoma with extensive osteolytic lesions and hypercalcemia
1Department of Internal Medicine, J.H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0002.
Southern Medical Journal
|November 1, 1991
Summary
Osteolytic lesions and hypercalcemia are rare in high-grade non-Hodgkin's lymphoma. This case highlights a young man with lymphoblastic lymphoma presenting with these symptoms, challenging typical associations.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Osteolytic lesions and hypercalcemia are typically linked to well-differentiated B-cell neoplasms like multiple myeloma.
- The co-occurrence of these symptoms with high-grade non-Hodgkin's lymphoma is considered rare in clinical practice.
Observation:
- A 20-year-old male presented with extensive osteolytic lesions and significant hypercalcemia (serum calcium 13.5 mg/dL).
- Notably, the patient exhibited no signs of lymphadenopathy, a common indicator in lymphoma cases.
Findings:
- The patient was diagnosed with non-T-cell lymphoblastic lymphoma.
- This diagnosis established a rare association between lymphoblastic lymphoma and the syndrome of osteolytic lesions and hypercalcemia.
Implications:
- This case expands the known clinical spectrum of non-T-cell lymphoblastic lymphoma.
- It underscores the importance of considering uncommon presentations of lymphoma, even in the absence of typical lymphadenopathy, when hypercalcemia and osteolytic lesions are present.