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Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

Tuberculosis

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

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Related Experiment Video

Updated: Jun 22, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

[Tuberculous lupus].

N El Fekih¹, B Fazaa, N Kerkeni

¹Service de dermatologie, hôpital Charles-Nicolle, boulevard du 9-Avril, Bab-Saadoun, 1006 Tunis, Tunisie. fekih.nadia@planet.tn

Medecine Et Maladies Infectieuses

|June 2, 2009

Summary

This summary is machine-generated.

This case study highlights an unusual presentation of cutaneous tuberculosis (tuberculous lupus) with extensive skin lesions and pulmonary involvement. Early diagnosis and antituberculous treatment were crucial for successful management.

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Last Updated: Jun 22, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Area of Science:

Dermatology
Infectious Diseases
Microbiology

Background:

Cutaneous tuberculosis (TB) represents a small fraction of extrapulmonary TB cases, presenting diverse clinical forms.
Lupus vulgaris, a common form of cutaneous TB, typically affects the head and neck.
Unusual presentations can complicate the diagnosis of cutaneous TB.

Observation:

A 29-year-old woman presented with plurifocal tuberculous lupus and severe pulmonary TB.
Histopathology revealed granuloma with caseum necrosis in skin lesions.
Diagnostic tests including skin PCR and sputum culture were negative.

Findings:

The patient had a positive Mantoux test.
Both cutaneous and pulmonary lesions showed positive response to antituberculous therapy.
The presence of caseum necrosis in this case was an unusual histological finding.

Implications:

This case underscores the importance of considering TB in patients with atypical skin lesions, even with negative microbiological cultures.
Unusual clinical and histological features of lupus vulgaris necessitate a high index of suspicion for accurate diagnosis.
Prompt initiation of antituberculous treatment is vital for managing complex cutaneous and pulmonary TB co-infections.