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Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks

Thomas Schleker1, Shigeki Nagai, Susan M Gasser

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

DNA Repair
|June 2, 2009
PubMed

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Restarting Stalled Replication Forks02:37

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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