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Regulation of cell proliferation and differentiation in the kidney

Neal I Alcalay1, Gregory B Vanden Heuvel

  • 1Department of Anatomy, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Frontiers in Bioscience (Landmark Edition)
|June 2, 2009
PubMed

Insights

The Cux1 transcription factor regulates cell cycle proteins and is developmentally expressed. Mouse models reveal its roles in development and disease, particularly in kidney development and polycystic kidney disease.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Mammalian cut proteins, including Cux1, are nuclear transcription factors.
  • Cux1 acts as a cell cycle-dependent regulator of cell cycle proteins.
  • Cux1 expression is developmentally regulated, indicating significant regulatory roles.

Purpose of the Study:

  • To review phenotypes from five transgenic mouse models of Cux1.
  • To discuss the role of Cux1 in kidney development and disease.

Main Methods:

  • Analysis of five existing transgenic mouse models of Cux1.
  • Review of literature on Cux1 function in development and disease.

Main Results:

  • Cux1 plays roles in hair growth, lung development, and genitourinary tract development.
  • Aberrant Cux1 expression is linked to polycystic kidney disease and cancer.

Conclusions:

  • Cux1 is a key regulator in mammalian development.
  • Dysregulation of Cux1 contributes to kidney disease pathogenesis.

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