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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
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Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
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Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Complement in Candida albicans infections.

Gunter Rambach1, Cornelia Speth

  • 1Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria.

Frontiers in Bioscience (Elite Edition)
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Candida albicans can cause infections in immunocompromised individuals. This study explores how Candida albicans evades the body's complement system, a key immune defense, and discusses potential complement-based therapies.

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Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Candida albicans is a common commensal organism in healthy individuals.
  • It can cause opportunistic infections, ranging from superficial to systemic, in immunocompromised hosts.
  • The complement system is a crucial part of the innate immune response against fungal pathogens like Candida.

Purpose of the Study:

  • To summarize the interactions between Candida albicans and the complement system.
  • To review Candida albicans' complement evasion strategies.
  • To provide an outlook on complement-based therapeutic strategies against Candida infections.

Main Methods:

  • Review of existing literature on Candida albicans-complement interactions.
  • Analysis of Candida albicans' immune evasion mechanisms.
  • Discussion of current and potential therapeutic applications of complement modulation.

Main Results:

  • Candida albicans employs various strategies to evade complement-mediated clearance.
  • The complement system initiates an effective antifungal response, but Candida's evasion tactics can undermine it.
  • Understanding these interactions is key to developing effective treatments.

Conclusions:

  • Candida albicans actively counteracts the complement system's antifungal activity.
  • Targeting complement pathways presents a promising avenue for novel antifungal therapies.
  • Further research into complement-based approaches is warranted for treating Candida infections.