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Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

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Complications of hypercalciuria.

Andrew Schwaderer¹, Tarak Srivastava

¹Division or Nephrology, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA. schwadea@pediatrics.ohio-state.edu

Frontiers in Bioscience (Elite Edition)

|June 2, 2009

Summary

Idiopathic hypercalciuria in children can cause various symptoms like kidney stones and pain. This review covers calcium metabolism, hypercalciuria types, consequences, and management strategies.

Area of Science:

Pediatric Nephrology
Metabolic Disorders

Background:

Idiopathic hypercalciuria is a frequent pediatric condition.
It manifests with diverse clinical signs including hematuria, voiding dysfunction, pain, nephrolithiasis, UTIs, and reduced bone density.

Purpose of the Study:

To provide a concise review of idiopathic hypercalciuria in children.
To cover calcium metabolism, clinical presentations, and evaluation/management approaches.

Main Methods:

Literature review of idiopathic hypercalciuria in pediatric populations.
Synthesis of information on calcium metabolism and clinical consequences.
Outline of diagnostic and therapeutic strategies.

Main Results:

Idiopathic hypercalciuria presents a spectrum of clinical issues in children.

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Understanding calcium metabolism is key to managing this disorder.

A systematic approach to evaluation and treatment is essential.

Conclusions:

Idiopathic hypercalciuria requires comprehensive understanding and management in pediatric care.
Early diagnosis and intervention can mitigate long-term complications.
This review offers a foundational guide for clinicians.