Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Conduction System of the Heart01:20

Conduction System of the Heart

The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
Conduction System of the Heart01:19

Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathological phenotypes of singleton stillbirth: A retrospective cohort study.

Acta obstetricia et gynecologica Scandinavica·2026
Same author

Esophageal epidermoid metaplasia: A rare condition in the pediatric population.

Journal of pediatric gastroenterology and nutrition·2024
Same author

Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor.

Cell communication and signaling : CCS·2024
Same author

Regulation of Proinflammatory Molecules and Tissue Factor by SARS-CoV-2 Spike Protein in Human Placental Cells: Implications for SARS-CoV-2 Pathogenesis in Pregnant Women.

Frontiers in immunology·2022
Same author

A Postmortem Portrait of the Coronavirus Disease 2019 (COVID-19) Pandemic: A Large Multi-institutional Autopsy Survey Study.

Archives of pathology & laboratory medicine·2021
Same author

A Rare Presentation of Common Arterial Trunk with Intact Ventricular Septum.

Journal of cardiovascular development and disease·2020
Same journal

Compositional and Functional Metabolic Shifts in the Endometrial Microbiota of Cows (<i>Bos taurus</i>) During the Transition Period: A Metagenomic Next-Generation Sequencing Approach.

Frontiers in bioscience (Elite edition)·2026
Same journal

Insights Into the Characterization and Application of <i>Pseudomonas taetrolens</i>.

Frontiers in bioscience (Elite edition)·2026
Same journal

Small Helper Ti-plasmid Coexisting With the <i>A281virF</i> Gene Encoding an F-Box-Like Protein Improves the Efficiency of T-DNA Transfer From <i>Agrobacterium</i> Cells to Plant Cells.

Frontiers in bioscience (Elite edition)·2026
Same journal

AAV9-Mediated Targeting of Defined Neuronal Populations in Spinal Cord Through Intrathecal Injection.

Frontiers in bioscience (Elite edition)·2026
Same journal

Progress in Bioengineering: An Extensive Examination of State-of-the-Art Innovations in the Development of Artificial Corneas.

Frontiers in bioscience (Elite edition)·2026
Same journal

Nitrosylcobalamin Selectively Targets Tumors via Cobalamin Uptake and Lysosomal Processing.

Frontiers in bioscience (Elite edition)·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Children
09:45

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Children

Published on: April 29, 2013

Cardiac conduction disorders in children.

Thora S Steffensen1, Enid Gilbert Barness

  • 1Department of Pathology and Cell Biology, University of South Florida and Tampa General Hospital, 2 Columbia Drive, Tampa, FL 33606, USA.

Frontiers in Bioscience (Elite Edition)
|June 2, 2009
PubMed
Summary
This summary is machine-generated.

Congenital short QT syndrome is a newly identified familial heart condition causing dangerous arrhythmias and sudden death. Molecular analysis is crucial for diagnosing this and other primary electrical heart diseases.

More Related Videos

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

Electrocardiogram Recordings in Anesthetized Mice using Lead II
04:16

Electrocardiogram Recordings in Anesthetized Mice using Lead II

Published on: June 20, 2020

Related Experiment Videos

Last Updated: Jun 22, 2026

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Children
09:45

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Children

Published on: April 29, 2013

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

Electrocardiogram Recordings in Anesthetized Mice using Lead II
04:16

Electrocardiogram Recordings in Anesthetized Mice using Lead II

Published on: June 20, 2020

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Cardiac conduction disorders can lead to fatal arrhythmias.
  • Several cardiomyopathies and channelopathies, including Long QT syndrome (LQTS) and Brugada syndrome, are well-established.
  • Congenital short QT syndrome (SQTS) is a primary electrical heart disease characterized by a shortened QT interval and life-threatening tachyarrhythmias.

Purpose of the Study:

  • To introduce and describe congenital short QT syndrome (SQTS) as a distinct familial primary electrical heart disease.
  • To highlight the association of SQTS with paroxysmal atrial and ventricular tachyarrhythmias and sudden cardiac death.
  • To emphasize the need for molecular analysis in diagnosing primary electrical heart diseases, including SQTS.

Main Methods:

  • Review of existing literature on primary electrical heart diseases.
  • Description of the clinical and genetic characteristics of congenital short QT syndrome.
  • Comparison with other known conduction disorders and cardiomyopathies.

Main Results:

  • Congenital short QT syndrome (SQTS) is characterized by a significantly shortened QT interval.
  • SQTS is associated with paroxysmal atrial and ventricular tachyarrhythmias, potentially leading to sudden cardiac death.
  • An autosomal dominant inheritance pattern is suggested for SQTS.
  • Catecholaminergic polymorphic ventricular tachycardia, another inherited arrhythmia, occurs without structural heart disease.

Conclusions:

  • Congenital short QT syndrome (SQTS) represents a novel familial primary electrical disorder.
  • Accurate diagnosis of SQTS and other cardiomyopathies necessitates molecular analysis, complementing histological findings.
  • Understanding these genetic heart conditions is vital for risk stratification and management to prevent sudden cardiac death.