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Updated: Jun 22, 2026
07:55
Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs
Published on: December 13, 2019
Integrins and extracellular matrices in pancreatic tissue engineering
Mansa Krishnamurthy1, Rennian Wang
1Childrens' Health Research Institute, University of Western Ontario, London, ON, Canada.
Frontiers in Bioscience (Scholar Edition)
|June 2, 2009
Summary
Integrin receptors and extracellular matrix interactions are crucial for pancreatic islet cell development, survival, and function. This review explores their role in tissue formation and potential applications in islet-based therapies.
Area of Science:
- Endocrinology
- Cell Biology
- Tissue Engineering
Background:
- Integrin receptors mediate cell-extracellular matrix (ECM) interactions, influencing cellular programs.
- These interactions are vital for the development, survival, and function of pancreatic islet cells.
Purpose of the Study:
- To review the role of integrin-ECM relationships in pancreatic tissue morphogenesis.
- To discuss the anti-apoptotic signaling pathways regulated by integrins.
- To explore the implications of integrin-ECM interactions in islet-based therapies.
Main Methods:
- Literature review of studies on integrin signaling in the endocrine pancreas.
- Analysis of ECM components and their interaction with integrin receptors.
- Examination of therapeutic strategies involving pancreatic islets.
Main Results:
- Integrin-ECM interactions are key regulators of pancreatic tissue development and morphogenesis.
- Integrins activate unique signaling pathways that confer anti-apoptotic properties to islet cells.
- Understanding these relationships is crucial for advancing islet transplantation and tissue engineering.
Conclusions:
- Integrin-ECM dynamics are fundamental to endocrine pancreas biology.
- Targeting integrin-ECM pathways holds promise for improving islet cell survival and function in therapeutic settings.
- Further research into these interactions can enhance regenerative medicine approaches for diabetes.
Related Concept Videos
01:10Integrins
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
01:13Cell-matrix's Response to Mechanical Forces
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
01:42The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
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01:24Overview of Cell-Matrix Interactions
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...