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Updated: Jun 22, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Pitfalls, problems, and progress in bronchopulmonary dysplasia.

Anita Bhandari¹, Vineet Bhandari

¹Division of Pediatric Pulmonology, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

|June 2, 2009

Summary

Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants. This review covers recent advances in BPD definition, pathogenesis, biomarkers, and management strategies, alongside long-term outcomes.

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Last Updated: Jun 22, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Area of Science:

Neonatology
Pediatric Pulmonology
Developmental Biology

Background:

Bronchopulmonary dysplasia (BPD) is a significant complication of preterm birth, characterized by chronic lung injury.
It affects a substantial number of premature infants, leading to long-term respiratory morbidity.
Understanding BPD's complexities is crucial for improving infant health outcomes.

Purpose of the Study:

To review recent advancements in bronchopulmonary dysplasia over the last decade, with a focus on the past five years.
To critically appraise current and novel management strategies for BPD in human neonates.
To summarize updated information on pathogenesis, genetic factors, biomarkers, and long-term outcomes of BPD.

Main Methods:

Comprehensive literature review focusing on studies published within the last 5-10 years.
Analysis of research concerning human neonates diagnosed with bronchopulmonary dysplasia.
Synthesis of data on definition changes, pathogenesis, genetic susceptibility, biomarkers, and therapeutic interventions.

Main Results:

Significant evolution in the definition and understanding of BPD pathogenesis.
Identification of novel biomarkers aiding in early diagnosis and risk stratification.
Critical appraisal of established and emerging therapies, highlighting areas of progress and unmet needs.
Summary of recent findings on the long-term pulmonary and neurodevelopmental sequelae in BPD survivors.

Conclusions:

Recent progress has refined our understanding and management of bronchopulmonary dysplasia.
Continued research into pathogenesis, genetics, and novel therapies is essential for further improving outcomes.
Long-term surveillance is critical for addressing the pulmonary and neurodevelopmental challenges faced by infants with BPD.