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Updated: Jun 22, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel furanylarylene arylsulfonylindolesulfonamides: synthesis and their antibacterial evaluation
Chennan Ramalingan1, In-Sook Lee, Young-Woo Kwak
1Department of Chemistry, Kyungpook National University, Taegu 702-701, Korea.
Abstract:
An array of furanylarylene arylsulfonylindolesulfonamides was synthesized through multi-step synthetic protocols involving bromination, stannylation, Stille cross coupling, reduction, arylsulfonylation, chlorosulfonylation, and condensation reactions. As a preliminary evaluation, these analogs were tested for antibacterial activity against a series of bacterial strains such as Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae using a two-fold serial dilution assay. Whereas analogs possessing unsubstitution, bromosubstitution, or methyl substitution on the benzene ring of benzenesulfonyl group were less active/inactive, the methoxy and chloro substituted counterparts were demonstrated to be comparatively more active. A few of them were found to exhibit better activity than the standard, streptomycin against selective organisms.
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