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Histone lysine methylation in genomic imprinting
David N Ciccone1, Taiping Chen
1Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
Epigenetics
|June 2, 2009
Summary
Genomic imprinting, controlled by DNA methylation, involves parent-specific gene expression. Emerging research suggests histone methylation also regulates imprinted genes and DNA methylation establishment.
Area of Science:
- Epigenetics
- Molecular Biology
- Genetics
Background:
- Genomic imprinting is an epigenetic process causing parent-specific gene expression in mammals.
- DNA methylation is the primary epigenetic mark regulating genomic imprinting.
- Imprints are established in germ cells and maintained throughout development.
Purpose of the Study:
- To review recent studies on the role of histone lysine methylation in genomic imprinting.
- To discuss the implications of histone methylation in regulating imprinted gene expression and DNA methylation maintenance.
Main Methods:
- Literature review of recent studies on epigenetic regulation of genomic imprinting.
- Analysis of the interplay between DNA methylation and histone modifications.
Main Results:
- Histone lysine methylation is crucial for regulating imprinted gene expression.
- Histone methylation may also play a role in establishing and maintaining DNA methylation imprints.
Conclusions:
- Histone methylation represents a key regulatory layer in genomic imprinting.
- Further research is needed to fully elucidate the mechanisms linking histone and DNA methylation in imprinting.
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