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Related Experiment Video

Updated: Jun 22, 2026

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

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Published on: June 15, 2018

Pain in progressive supranuclear palsy.

Ilana Schlesinger¹, Ana Klesier, David Yarnitsky

¹Department of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, Israel. i_schles@rambam.health.gov.il

Clinical Neuropharmacology

|June 2, 2009

Summary

This summary is machine-generated.

Progressive supranuclear palsy can cause significant neck pain. Intravenous lidocaine effectively relieved this pain, offering a potential new treatment option for dystonia management.

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Area of Science:

Neurology
Pain Management
Pharmacology

Background:

Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease.
Neck pain is a debilitating symptom in some PSP patients.
Current treatments for dystonia-related pain in PSP are limited.

Observation:

A patient with PSP presented with severe, intractable neck pain.
Intravenous administration of lidocaine resulted in significant pain alleviation.
The pain relief was sustained over an extended period post-infusion.

Findings:

Lidocaine demonstrated efficacy in managing neuropathic pain associated with dystonia in PSP.
The patient experienced improved quality of life due to pain reduction.
This suggests a potential therapeutic role for lidocaine in similar cases.

Implications:

Lidocaine may be a valuable option for refractory neck pain in progressive supranuclear palsy.
Further research is warranted to explore lidocaine's mechanism in dystonia pain.
Consideration of intravenous lidocaine could improve patient outcomes and quality of life in PSP.