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Nocturnal reflux in children and adolescents with persistent asthma and gastroesophageal reflux

Lucas Dalle Molle1, Helena A S Goldani, Simone C Fagondes

  • 1Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre-UFRGS, Porto Alegre, RS, Brazil. lucasdm@terra.com.br

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|June 2, 2009
PubMed

Insights

Nocturnal gastroesophageal reflux (GER) is common in children with persistent asthma, affecting nearly half of patients. However, this reflux did not correlate with their lung function test results.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology
  • Respiratory Medicine

Background:

  • Nocturnal gastroesophageal reflux (GER) is linked to respiratory symptoms in adults.
  • The study investigated the prevalence of nocturnal GER in children with persistent asthma.

Purpose of the Study:

  • To determine the prevalence of nocturnal GER using prolonged intraesophageal pH monitoring in children with persistent asthma.
  • To compare GER prevalence with spirometry results.

Main Methods:

  • Thirty-eight children with persistent asthma underwent prolonged intraesophageal pH monitoring and spirometry.
  • GER was defined as a reflux index (RI) > 5%.
  • Pulmonary function was assessed via FVC, FEV(1), FEF(25-75%), and FEV(1)/FVC ratio.

Main Results:

  • GER prevalence was 47.3% in children with persistent asthma.
  • Reflux index was similar in supine (nocturnal) and upright positions.
  • No significant correlation was found between GER and pulmonary function parameters (FVC, FEV(1), FEF(25-75%)).

Conclusions:

  • A high prevalence of GER exists in children and adolescents with persistent asthma.
  • GER in this population is equally distributed in nocturnal and upright positions.
  • GER was not correlated with pulmonary function tests in children with persistent asthma.
Abstract

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