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Updated: Jun 22, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling

Alexander Hergovich1, Brian A Hemmings

  • 1Friedrich Miescher Institute for Biomedical Research, Growth Control, Maulbeerstrasse 66, Basel, Switzerland. hergo@fmi.ch

Biofactors (Oxford, England)
|June 2, 2009
PubMed

Insights

The NDR/LATS kinases, crucial in Hippo signaling, regulate cell growth and apoptosis. This review details their activation and role in tumor suppression via the Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ network.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The NDR/LATS kinase family, part of the AGC group, is vital for cellular regulation.
  • Activation requires phosphorylation, influenced by MOB coactivators and MST kinases.
  • LATS kinases are central to Hippo/SWH tumor suppressor pathways.

Purpose of the Study:

  • To review the Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ network, known as mammalian Hippo signaling.
  • To summarize molecular activation mechanisms of NDR/LATS kinases.
  • To elucidate the role of these networks in mammalian cellular transformation.

Main Methods:

  • Literature review of recent studies on Hippo signaling.
  • Analysis of molecular activation pathways of NDR/LATS kinases.
  • Examination of the role of YAP and TAZ proto-oncogenes.

Main Results:

  • NDR/LATS kinases require phosphorylation for activation.
  • MOB binding facilitates autophosphorylation, while MST kinases directly phosphorylate NDR/LATS.
  • LATS kinases regulate cell proliferation and apoptosis through YAP and TAZ.

Conclusions:

  • The Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ network is critical for maintaining cellular homeostasis.
  • Dysregulation of this network is implicated in mammalian cellular transformation and cancer.
  • Further understanding of Hippo signaling is essential for cancer research.

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