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Published on: July 23, 2016
Sustained elevation in intraocular pressure associated with intravitreal bevacizumab injections
Malik Y Kahook1, Alan E Kimura, Lisa J Wong
1Department of Ophthalmology, Rocky Mountain Lions Eye Institute, University of Colorado at Denver, Aurora 80045, USA.
Abstract:
This retrospective case series reports sustained elevation of intraocular pressure (IOP) after single or repeated intravitreal injections of bevacizumab (Avastin; Genentech, San Francisco, CA) for wet age-related macular degeneration (AMD). All six cases experienced significant and sustained elevation in IOP after single or repeated intravitreal injections of bevacizumab. Initiation or advancement of IOP-lowering therapy was required in all cases. The results support the need for further studies investigating the incidence of this potential side effect and the need for close long-term surveillance of IOP after injection of bevacizumab, particularly in patients with glaucoma or suspected glaucoma. Future in vitro and in vivo studies are needed to better understand the reasons for this observed phenomenon.
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