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Related Experiment Video

Updated: Jun 22, 2026

Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation
10:21

Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation

Published on: December 25, 2017

The tissue diagnostic instrument.

Paul Hansma1, Hongmei Yu, David Schultz

  • 1Department of Physics, University of California, Santa Barbara, California 93106, USA.

The Review of Scientific Instruments
|June 3, 2009
PubMed
Summary
This summary is machine-generated.

A new tissue diagnostic instrument (TDI) measures mechanical properties of tissues to detect diseases like cancer and osteoarthritis. This device offers a non-invasive method for early disease detection in patients.

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Last Updated: Jun 22, 2026

Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation
10:21

Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation

Published on: December 25, 2017

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pathology

Background:

  • Tissue mechanical properties are linked to extracellular matrix composition and organization.
  • Alterations in tissue mechanics are indicative of various diseases, including intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay.

Purpose of the Study:

  • To introduce a novel tissue diagnostic instrument (TDI) capable of probing mechanical properties of both normal and diseased soft and hard tissues.
  • To assess the TDI's ability to differentiate between healthy and pathological tissue states in various biological systems.
  • To evaluate the TDI's potential for in-vivo clinical application and research.

Main Methods:

  • The tissue diagnostic instrument (TDI) utilizes indentation tests to quantify mechanical parameters such as elastic modulus and hardness.
  • The device is designed for both laboratory and patient-side use, employing local anesthesia and sterile probe assemblies for in-vivo testing.
  • Specific applications include differentiating spinal disk regions, assessing cartilage degeneration, analyzing mammary gland tissues, quantifying dentin properties, and performing bone indentation tests.

Main Results:

  • The TDI successfully distinguished between nucleus and annulus of spinal disks, young and degenerated cartilage, and normal and cancerous mammary glands.
  • The instrument accurately quantified elastic modulus and hardness of wet dentin and performed indentation tests on bone tissue.
  • In-vivo patient tests using the TDI reported no pain or complications, indicating its clinical feasibility.

Conclusions:

  • The tissue diagnostic instrument (TDI) is a versatile tool for assessing tissue mechanical properties in diverse biological contexts.
  • The TDI demonstrates significant potential for facilitating research into disease mechanisms and enabling early detection across various tissue types, including in living organisms and plants.
  • The instrument's non-invasive nature and demonstrated clinical feasibility pave the way for broader applications in diagnostics and biomedical research.