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Updated: Jun 22, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
Treatment of HBV-related cirrhosis
Anais Vallet-Pichard1, Vincent Mallet, Charlotte E Costentin
1Université Paris Descartes, APHP, INSERM U.567, Hôpital Cochin, Unité d'Hépatologie, 27 rue du faubourg Saint Jacques, Paris Cedex 14, France. anais.vallet-pichard@cch.aphp.fr
Abstract:
The goal of antiviral therapy in HBV cirrhotic patients is to prevent progression of the disease to decompensated cirrhosis, end-stage liver disease, hepatocellular carcinoma and death. This goal can be achieved if HBV replication can be suppressed, leading to biochemical remission, histological improvement and prevention of complications. If finite treatment with pegylated interferon is not contraindicated in compensated cirrhosis, long-term treatment with nucleoside/nucleotide analogues is recommended in patients with HBV-related cirrhosis, especially in decompensated cirrhosis. Patients with cirrhosis require careful monitoring to detect resistance and prevent flares, and also to screen for hepatocellular carcinoma, portal hypertension and liver failure.
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