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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
Temporal alterations in brain water diffusivity in neonatal meningitis.
Gyanendra K Malik1, Abhishek Yadav, Richa Trivedi
1Department of Pediatrics, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India.
Acta Paediatrica (Oslo, Norway : 1992)
|June 3, 2009
Summary
Quantitative apparent diffusion coefficient (ADC) using diffusion-weighted imaging (DWI) can detect early brain changes in neonatal meningitis. Reduced ADC in affected infants correlates with poorer neurodevelopmental outcomes.
Area of Science:
- Neonatal neurology
- Pediatric radiology
- Neuroimaging
Background:
- Neonatal meningitis can lead to long-term neurological deficits.
- Early detection of brain injury is crucial for timely intervention.
Purpose of the Study:
- To compare changes in apparent diffusion coefficient (ADC) in neonatal meningitis using serial diffusion-weighted imaging (DWI).
- To assess the correlation between ADC changes and neurodevelopmental outcomes.
Main Methods:
- Diffusion-weighted imaging (DWI) and conventional MRI were performed on 30 neonates with meningitis and 12 controls.
- Apparent diffusion coefficient (ADC) was quantified in the periventricular white matter at baseline and 21 days.
- Neurodevelopmental assessment using the Indian adaptation of the Bayley Scales of Infant Development (BSID) was conducted at 3 months.
Main Results:
- Patients with abnormal DWI findings (alone or with abnormal conventional MRI) showed significantly reduced ADC compared to controls at baseline (p = 0.001).
- No significant differences in ADC were observed between patient groups and controls at follow-up.
- Significantly reduced neurodevelopmental scores were observed in patient groups compared to controls.
Conclusions:
- Quantitative ADC measurements may facilitate early detection of meningitis-induced hypoxia in the neonatal brain parenchyma.
- Reduced ADC in neonatal meningitis is associated with abnormal motor and mental development.
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