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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

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Related Experiment Video

Updated: Jun 22, 2026

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Acne scarring treatment using skin needling.

G Fabbrocini1, N Fardella, A Monfrecola

  • 1Department of Systematic Pathology, Division of Clinical Dermatology, University of Naples Federico II, Naples, Italy. gafabbro@unina.it

Clinical and Experimental Dermatology
|June 3, 2009
PubMed
Summary

Skin needling effectively treats acne rolling scars, significantly improving their appearance after just two sessions. This minimally invasive procedure offers aesthetic benefits with no reported side effects like hyperpigmentation.

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Published on: October 25, 2018

Area of Science:

  • Dermatology
  • Aesthetic Medicine

Background:

  • Acne affects a significant portion of the population, often leading to persistent, difficult-to-treat scars.
  • Rolling acne scars can cause considerable aesthetic distress and impact patient self-esteem.

Purpose of the Study:

  • To evaluate the efficacy of skin needling for treating rolling acne scars.
  • To confirm the clinical usefulness of this minimally invasive dermatological procedure.

Main Methods:

  • A study involving 32 patients with acne rolling scars treated over two sessions.
  • Photographic documentation and silicone rubber casts were used to assess scar depth and surface irregularity.
  • Statistical analysis included the sign test and fast Fourier transformation (FFT).

Main Results:

  • All patients demonstrated a significant reduction in rolling scar severity after two skin needling sessions.
  • Overall aesthetic improvement was observed in all participants.
  • No adverse effects, such as hyperpigmentation or visible procedural signs, were reported.

Conclusions:

  • Skin needling provides an immediate and effective treatment for acne rolling scars.
  • The procedure demonstrates advantages over alternative scar treatment methods.