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Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia
Lauren Véronèse1, Olivier Tournilhac, Pierre Verrelle
1Univ Clermont 1, Fac Médecine, Histologie Embryologie Cytogénétique, Clermont-Ferrand F-63001, France.
Leukemia Research
|June 3, 2009
Summary
Myeloid cell leukemia-1 (MCL-1) gene expression predicts prognosis in B-cell chronic lymphocytic leukemia (B-CLL). Vascular endothelial growth factor (VEGF) upregulates MCL-1 and impacts patient outcomes in B-CLL.
Area of Science:
- Oncology
- Molecular Biology
- Hematology
Background:
- Myeloid cell leukemia-1 (MCL-1) gene expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL).
- Vascular and endothelial growth factor (VEGF) and interleukin-6 (IL-6) can upregulate MCL-1 through autocrine signaling loops.
Purpose of the Study:
- To investigate the correlation between MCL-1 gene expression and VEGF/IL-6 levels in B-CLL patients.
- To determine the prognostic significance of VEGF and IL-6 in B-CLL.
- To explore the role of VEGF as an in vivo regulator of MCL-1 in B-CLL.
Main Methods:
- Analysis of MCL-1, VEGF, and IL-6 mRNA levels in 88 B-CLL patients.
- Statistical correlation analysis between gene expression levels.
- Prognostic evaluation based on VEGF and IL-6 expression.
Main Results:
- A strong correlation was observed between MCL-1 gene expression and VEGF levels (P<10(-7)).
- No significant correlation was found between MCL-1 and IL-6 mRNA levels.
- VEGF expression, but not IL-6, significantly influenced patient prognosis.
Conclusions:
- VEGF is a potential positive in vivo autocrine regulator of MCL-1 in B-CLL.
- VEGF signaling inhibition may offer a therapeutic strategy for B-CLL treatment.
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