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Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia
Lauren Véronèse1, Olivier Tournilhac, Pierre Verrelle
1Univ Clermont 1, Fac Médecine, Histologie Embryologie Cytogénétique, Clermont-Ferrand F-63001, France.
Abstract:
Expression of the anti-apoptotic myeloid cell leukemia-1 (MCL-1) gene is a novel prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL). Vascular and endothelial growth factor (VEGF) and interleukin-6 (IL-6) are able to upregulate MCL-1 via autocrine signaling loops. In 88 B-CLL patients, we found a strong correlation of MCL-1 gene expression with VEGF (P<10(-7)) but not with IL-6 mRNA levels. VEGF but not IL-6 expression influenced patient prognosis. VEGF may be a positive autocrine in vivo regulator of MCL-1 in B-CLL. Inhibition of VEGF and its signaling may prove to be useful in the treatment of B-CLL patients.
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