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Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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The OptIPuter microscopy demonstrator: enabling science through a transatlantic lightpath.

M Ellisman¹, T Hutton, A Kirkland

¹National Centre for Microscopy and Imaging Research, University of California, San Diego, CA 92093, USA.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences

|June 3, 2009

Summary

The OptIPuter project created a dedicated network for remote, concurrent use of electron microscopes in Oxford and San Diego. This advanced infrastructure supports materials and biological science research, enabling future remote microscopy projects.

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Area of Science:

Advanced microscopy
Networked scientific instruments
Materials science and biological science

Background:

Concurrent and remote access to world-class electron microscopes is crucial for scientific advancement.
Existing infrastructure limited collaborative research between geographically dispersed facilities.

Purpose of the Study:

To establish a dedicated network infrastructure enabling concurrent and remote operation of electron microscopes.
To create a permanent, high-performance link between microscopy centers in Oxford and San Diego.
To lay the groundwork for future remote control of diverse microscopy systems, including optical and electron microscopy.

Main Methods:

Construction of a dedicated network infrastructure utilizing UK Lightpath and US Starlight systems.
Integration of electron microscopes, computational resources, and data storage.
Upgrading Microsoft cluster software to High Performance Computing (HPC) Server 2008 for interoperable clients.

Main Results:

A permanent network link was established between Oxford and San Diego microscopy centers.
The system enables concurrent and remote usage of electron microscopes for materials and biological science.
The infrastructure supports the development of interoperable clients through HPC basic profile implementation.

Conclusions:

The OptIPuter demonstrator project successfully created a robust, networked microscopy system.
This permanent link facilitates ongoing and future collaborative research between international sites.
The established infrastructure provides a foundation for expanding remote control capabilities to other microscopy types.