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Updated: Jun 22, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Digital ulcers: overt vascular disease in systemic sclerosis.
V Steen1, C P Denton, J E Pope
1Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA. steenv@georgetown.edu
Rheumatology (Oxford, England)
|June 3, 2009
Summary
Raynaud
Area of Science:
- Rheumatology and Immunology
- Vascular Medicine
Background:
- Raynaud's phenomenon (RP) affects 95% of systemic sclerosis (SSc) patients.
- Digital ulcers (DUs) develop in 30% of SSc patients annually, causing significant morbidity.
- Current DU treatments lack definitive efficacy, relying on empirical approaches.
Purpose of the Study:
- To evaluate the efficacy of bosentan in reducing new digital ulcers in SSc patients.
- To provide an approved therapeutic option for SSc-associated DUs.
Main Methods:
- Review of clinical data and treatment outcomes for SSc patients with DUs.
- Analysis of the impact of dual endothelin receptor antagonist therapy.
Main Results:
- Bosentan, a dual endothelin receptor antagonist, is now approved in Europe.
- Bosentan demonstrates potential in reducing the incidence of new DUs in SSc patients.
Conclusions:
- Bosentan offers a new therapeutic hope for managing DUs in SSc.
- Targeted endothelin receptor antagonism represents a significant advancement in SSc DU treatment.
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