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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Coronary Artery Disease III: Clinical Manifestations

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Related Experiment Video

Updated: Jun 22, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Cardiac complications of systemic sclerosis.

A Kahan1, G Coghlan, V McLaughlin

  • 1Department of Rheumatology A, Cochin Hospital, University of Paris Descartes, AP-HP, Paris, France. andre.kahan@cch.aphp.fr

Rheumatology (Oxford, England)
|June 3, 2009
PubMed
Summary

Systemic sclerosis (SSc) often involves subclinical cardiac issues, potentially leading to fibrosis and heart failure. Early screening with echocardiography and NT-proBNP is recommended for SSc patients to detect cardiac symptoms.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Area of Science:

  • Cardiology
  • Rheumatology
  • Systemic Sclerosis

Background:

  • Subclinical cardiac involvement is common in systemic sclerosis (SSc).
  • Overt cardiac manifestations in SSc correlate with poor prognosis and management challenges.

Observation:

  • Primary myocardial disease in SSc is hypothesized to stem from microvascular ischemia.
  • Early, undetected cardiac changes can silently progress to myocardial fibrosis.
  • Symptoms like arrhythmia and heart failure can manifest abruptly in SSc patients.

Findings:

  • Annual echocardiography and NT-proBNP evaluation are practical screening methods for SSc patients.
  • These screenings aim to anticipate cardiac symptom development.

Implications:

  • Limited evidence exists for specific therapies, but early treatment with calcium channel blockers and ACE inhibitors may enhance myocardial function.
  • Standard management is advised for overt cardiac disease in SSc.
  • Further research is needed to determine if early intervention can halt the progression of life-threatening cardiac complications in SSc.