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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

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Published on: November 17, 2017

Targeting atherosclerosis by using modular, multifunctional micelles.

David Peters¹, Mark Kastantin, Venkata Ramana Kotamraju

¹Vascular Mapping Center, Burnham Institute for Medical Research, University of California, Santa Barbara, 3119 Biology II Building, CA 93106-9610, USA.

Proceedings of the National Academy of Sciences of the United States of America

|June 3, 2009

Summary

This summary is machine-generated.

Novel nanoparticles target atherosclerotic plaque surface clots for improved diagnostics and therapeutics. These targeted micelles deliver drugs like hirulog specifically to plaque sites, enhancing treatment efficacy.

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Area of Science:

Biomedical Engineering
Nanotechnology
Cardiovascular Research

Background:

Atherosclerotic plaques contain subtle surface clots, representing a potential target for intervention.
Nanoparticle-based systems offer a novel approach for both diagnosing and treating atherosclerosis.

Purpose of the Study:

To develop and evaluate modular multifunctional micelles for targeting atherosclerotic plaques.
To assess the plaque-targeting capabilities and drug delivery efficiency of these novel nanoparticles.

Main Methods:

Development of modular micelles incorporating a targeting peptide (CREKA), a fluorophore, and a drug (hirulog).
In vivo studies using ApoE-null mice on a high-fat diet to model atherosclerosis.
Evaluation of micelle binding to atherosclerotic plaques and drug delivery to targeted sites.

Main Results:

Fluorescent micelles successfully targeted atherosclerotic plaques in mice, binding to the entire plaque surface.
Micelles concentrated at plaque shoulders, areas associated with rupture risk.
Targeted micelles delivered a higher concentration of hirulog to plaques compared to untargeted micelles.

Conclusions:

Modular multifunctional micelles are effective in targeting atherosclerotic plaque surface clots.
These nanoparticles show promise for enhanced diagnostic imaging and targeted therapeutic delivery in atherosclerosis.
The CREKA peptide facilitates specific binding to clotted plasma proteins on plaques.