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Updated: Jun 22, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

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High-quality cost-effective compound management support for HTS.

Maximiliano Zaragoza-Sundqvist¹, Hans Eriksson, Mattias Rohman

¹Department of Lead Generation, AstraZeneca R&D, Mölndal, Sweden. maximiliano.zaragoza-sundqvist@astrazeneca.com

Journal of Biomolecular Screening

|June 3, 2009

Summary

Acoustic droplet ejectors (ADEs) revolutionized high-throughput screening by enabling noncontact dispensing. This technology improves assay quality, reduces sample volumes, and cuts costs, making 1536-well plate formats routine.

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Area of Science:

Biotechnology
Assay Development
Liquid Handling Automation

Background:

Traditional contact liquid handlers presented challenges in high-throughput screening, including method development and instrument fine-tuning for 1536-well plates.
The introduction of acoustic droplet ejectors (ADEs) marked a significant advancement in noncontact liquid handling technology.

Purpose of the Study:

To evaluate the impact of acoustic droplet ejectors (ADEs) on high-throughput screening and compound management.
To highlight the benefits of noncontact dispensing in terms of assay quality, cost reduction, and efficiency.

Main Methods:

Implementation of acoustic droplet ejectors (ADEs) for noncontact liquid dispensing.
Transitioning assays to high-density 1536-well plate formats.
Integration of automation-friendly solutions like plate desealers.

Main Results:

ADEs significantly enhanced accuracy and precision, enabling the use of lower sample volumes.
The technology facilitated the reliable adoption of 1536-well plate formats, reducing preparation efforts.
Noncontact dispensing contributed to substantial cost savings and waste reduction in screening processes.

Conclusions:

Acoustic droplet ejectors have transformed high-throughput screening by offering superior performance and cost-effectiveness.
Noncontact dispensing with ADEs streamlines compound management and assay-ready plate preparation.
While contact dispensing has specific applications, noncontact methods offer significant advantages for overall cost and waste control.