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Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model

Satoshi Hagiwara1, Hideo Iwasaka, Akira Hasegawa

  • 1Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka-Hasamamachi, Yufu City, Oita, Japan. saku@med.oita-u.ac.jp

Critical Care Medicine
|June 3, 2009
PubMed
Summary

Hyperglycemia worsens cardiac function during inflammation, but insulin therapy mitigates these effects. This study in rats shows insulin protects against inflammation and improves heart function, highlighting its therapeutic potential.

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