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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Protection from EAE by IL-4Ralpha(-/-) macrophages depends upon T regulatory cell involvement

Paula Keating1, David O'Sullivan, Joanna B Tierney

  • 1School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.

Immunology and Cell Biology
|June 3, 2009
PubMed
Summary

Mice lacking the interleukin-4 receptor alpha (IL-4Ralpha) showed reduced experimental autoimmune encephalomyelitis (EAE) severity. This protection was linked to regulatory T cells (Tregs) and macrophages, not Th1/Th17 responses.

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