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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Lipids: Dietary Sources and Requirements

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Related Experiment Video

Updated: Jun 22, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Update on strategies to increase HDL quantity and function.

Danielle Duffy1, Daniel J Rader

  • 1Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Nature Reviews. Cardiology
|June 3, 2009
PubMed
Summary
This summary is machine-generated.

Low high-density lipoprotein (HDL) cholesterol levels predict cardiovascular events. New therapies aim to boost HDL cholesterol and improve its protective functions against atherosclerosis.

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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

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Last Updated: Jun 22, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Pharmacology

Background:

  • Low levels of high-density lipoprotein (HDL) cholesterol are a significant risk factor for atherosclerotic cardiovascular events.
  • HDL is thought to protect against atherosclerosis via reverse cholesterol transport and other beneficial effects like anti-inflammation and antioxidation.

Purpose of the Study:

  • To review emerging therapeutic strategies for increasing HDL cholesterol levels.
  • To discuss approaches aimed at enhancing HDL functionality for atherosclerosis treatment.

Main Methods:

  • Review of current research and development in HDL-targeted therapies.
  • Analysis of mechanisms underlying HDL's protective effects and therapeutic potential.

Main Results:

  • HDL's multifaceted role in cardiovascular protection is complex.
  • Several novel therapeutic strategies are under investigation to modulate HDL levels and function.

Conclusions:

  • HDL is a promising therapeutic target for atherosclerosis.
  • Developing strategies to increase HDL cholesterol and improve its function holds potential for treating cardiovascular disease.