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Update on strategies to increase HDL quantity and function

Danielle Duffy1, Daniel J Rader

  • 1Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Nature Reviews. Cardiology
|June 3, 2009
PubMed

Insights

Low high-density lipoprotein (HDL) cholesterol levels predict cardiovascular events. New therapies aim to boost HDL cholesterol and improve its protective functions against atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Pharmacology

Background:

  • Low levels of high-density lipoprotein (HDL) cholesterol are a significant risk factor for atherosclerotic cardiovascular events.
  • HDL is thought to protect against atherosclerosis via reverse cholesterol transport and other beneficial effects like anti-inflammation and antioxidation.

Purpose of the Study:

  • To review emerging therapeutic strategies for increasing HDL cholesterol levels.
  • To discuss approaches aimed at enhancing HDL functionality for atherosclerosis treatment.

Main Methods:

  • Review of current research and development in HDL-targeted therapies.
  • Analysis of mechanisms underlying HDL's protective effects and therapeutic potential.

Main Results:

  • HDL's multifaceted role in cardiovascular protection is complex.
  • Several novel therapeutic strategies are under investigation to modulate HDL levels and function.

Conclusions:

  • HDL is a promising therapeutic target for atherosclerosis.
  • Developing strategies to increase HDL cholesterol and improve its function holds potential for treating cardiovascular disease.

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