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Related Experiment Videos

[Transdermal estrogen treatment. A placebo controlled study].

O E Iversen1, A B Eid, K H Johannesen

  • 1Kvinneklinikken, Haukeland sykehus, Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|August 30, 1991
PubMed
Summary

Transdermal oestrogen therapy (Estraderm) significantly reduced hot flushes and improved wellbeing in women experiencing climacteric complaints. This treatment effectively restored hormone levels and lowered systolic blood pressure.

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Area of Science:

  • Endocrinology
  • Menopause Research

Background:

  • Climacteric complaints significantly impact women's quality of life.
  • Hormone replacement therapy is a common treatment for menopausal symptoms.

Purpose of the Study:

  • To evaluate the efficacy of transdermal oestrogen therapy (Estraderm) for managing climacteric complaints.
  • To assess the effects of Estraderm on hormonal levels and physiological parameters.

Main Methods:

  • A double-blind, crossover study design was employed.
  • 22 women with climacteric complaints participated in the trial.
  • Treatment effects were assessed through symptom reporting and biochemical measurements.

Main Results:

  • Significant reduction in the number and intensity of hot flushes (approx. 80%).

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  • Improvements noted in general wellbeing, sleep quality, and energy levels.
  • Increased serum oestradiol and decreased FSH levels observed; systolic blood pressure lowered.

    • Conclusions:

    • Transdermal oestrogen therapy (Estraderm) is effective for treating climacteric complaints.
    • The treatment demonstrates a favorable hormonal and symptomatic profile.
    • Estraderm is a suitable option for women seeking relief from menopausal symptoms.