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Updated: Jun 22, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Bruxism affects stress responses in stressed rats
Chikatoshi Sato1, Sadao Sato, Hirofumi Takashina
1Department of Craniofacial Growth and Development Dentistry, Research Institute of Occlusion Medicine, Research Center of Brain and Oral Science, Kanagawa Dental College, Yokosuka, Kanagawa, Japan. satochi@kdcnet.ac.jp
Abstract:
It has been proposed that suppression of stress-related emotional responses leads to the simultaneous activation of both sympathetic and parasympathetic divisions of the autonomic nervous system (ANS) and that the expression of these emotional states has a protective effect against ulcerogenesis. In the present study, we investigated whether stress-induced bruxism activity (SBA) has a physiological effect of on the stress-induced changes of the stomach, thymus, and spleen as well as blood leukocytes, cortisol, and adrenaline. This study demonstrated that SBA attenuated the stress-induced ulcer genesis as well as degenerative changes of thymus and spleen. SBA also attenuated increases of adrenaline, cortisol, and neutrophils in the blood. In conclusion, expression of aggression through SBA during stress exposure attenuates both stress-induced ANS response, including gastric ulcer formation.
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