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Updated: Jun 22, 2026

Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
Published on: February 25, 2011
A comparison among the models proposed to explain the origin of the tRNA molecule: A synthesis
1Institute of Genetics and Biophysics, 'Adriano Buzzati Travers,' CNR, Naples, Napoli, Italy. digiulio@igb.cnr.it
Abstract:
A comparison is made among all the models proposed to explain the origin of the tRNA molecule. The conclusion reached is that, for the model predicting that the tRNA molecule originated after the assembly of two hairpin-like structures, molecular fossils have been found in the half-genes of the tRNAs of Nanoarchaeum equitans. These might be the witnesses of the transition stage predicted by the model through which the evolution of the tRNA molecule passed, thus providing considerable corroboration for this model.
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