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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts
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HOX D13 expression across 79 tumor tissue types.

Monica Cantile1, Renato Franco, Adrienne Tschan

  • 1Department of Clinical & Experimental Medicine, Federico II University Medical School, Naples, Italy.

International Journal of Cancer
|June 3, 2009
PubMed
Summary

HOXD13 homeoprotein expression is altered in most cancers, with decreased levels in pancreatic tumors negatively impacting patient prognosis. This study offers a broad overview of HOX protein expression in human carcinogenesis.

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • HOX genes, including HOXD13, are crucial for normal development and cellular processes.
  • Dysregulated HOXD13 expression is implicated in various cancers like breast cancer, melanoma, cervical cancer, and astrocytomas.

Purpose of the Study:

  • To investigate the epidemiology of HOXD13 expression across diverse human tissues and its role in carcinogenesis.
  • To provide a comprehensive overview of HOXD13 homeoprotein expression in normal and neoplastic tissues.

Main Methods:

  • Utilized microarray technology to analyze HOXD13 homeoprotein expression in over 4,000 normal and neoplastic tissue samples, covering 79 tumor categories.
  • Validated HOXD13 mRNA expression in selected tumor types.

Main Results:

  • HOXD13 expression differs significantly between normal tissues and corresponding tumors; 57.7% of cancers show increased expression compared to 16.1% of normal tissues.
  • Pancreatic and stomach tumors exhibit a contrasting trend with decreased HOXD13 expression.
  • Negative HOXD13 homeoprotein expression in pancreatic cancer correlates with significantly poorer patient prognosis, irrespective of tumor stage.

Conclusions:

  • This study presents the first large-scale overview of HOX protein expression in human normal and neoplastic tissues.
  • Pancreatic cancer is identified as a tumor type significantly affected by HOXD13 homeoprotein deregulation.
  • Homeoproteins, like HOXD13, are associated with human cancerogenesis, highlighting their potential as biomarkers or therapeutic targets.