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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

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Published on: September 18, 2013

Physical activity reduces prostate carcinogenesis in a transgenic model.

Karyn A Esser1, Clifford E Harpole, Gail S Prins

  • 1Department of Physiology, University of Kentucky, Lexington, Kentucky, USA. kaesse2@uky.edu

The Prostate
|June 3, 2009
PubMed
Summary

Regular exercise may delay or reduce prostate cancer progression. Studies show that mice running over 5 km/day had significantly less advanced prostate pathology compared to those running less. This suggests a dose-dependent relationship between physical activity and cancer inhibition.

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Area of Science:

  • Oncology
  • Exercise Science
  • Genetics

Background:

  • Epidemiological studies suggest a link between physical activity and reduced prostate cancer risk.
  • Animal studies corroborate this, showing exercise can inhibit carcinogenesis.
  • Increased exercise intensity correlates with greater inhibition of cancer development.

Purpose of the Study:

  • To investigate the effect of voluntary wheel running on prostate cancer progression in a transgenic mouse model.
  • To determine if physical activity influences the development of prostatic intraepithelial neoplasia (PIN) and local invasion.

Main Methods:

  • C3(1)Tag transgenic mice, predisposed to prostate cancer, were used.
  • Mice engaged in voluntary wheel running for 10 weeks.
  • Prostates were collected and histopathology was performed to assess low-grade and high-grade PIN.

Main Results:

  • Mice running >5 km/day showed 83% of dorsolateral prostates within normal limits, versus 43% in the <5 km/day group (p=0.16).
  • A dose-dependent relationship was observed between running distance and reduced advanced pathology.
  • None of the mice running >5 km/day had advanced pathology, compared to 43% in the <5 km/day group (p=0.05).

Conclusions:

  • Wheel running activity in transgenic mice appears to delay or diminish prostate cancer progression in a dose-dependent manner.
  • These findings support the role of exercise in decreasing prostate cancer progression.
  • A transgenic animal model is established for future mechanistic studies.