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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Method for detecting quantitative differences in the parameters of involuntary effort fluctuations in healthy
Y A Bedrov1, O E Dick, S P Romanov
1I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. bedrovya@peterstar.ru
Bulletin of Experimental Biology and Medicine
|June 4, 2009
Abstract:
The aim of the study was to detect quantitative differences in the parameters of involuntary effort fluctuations in healthy volunteers and patients with Parkinson's syndrome. Using a mathematical model, the process of isometric effort maintenance was separated into rapid (involuntary) and slow (voluntary) constituents. Significant differences were detected for the attenuation coefficient of fluctuations in the involuntary constituent, but not for the frequency.
