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Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive

Cheng-Lun Wu1, Chun-Lin Lee, Tzu-Ming Pan

  • 1Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, Republic of China.

Journal of Agricultural and Food Chemistry
|June 4, 2009
PubMed

Insights

Red mold dioscorea (RMD) significantly lowers blood pressure in rats, outperforming red mold rice (RMR). RMD demonstrates greater antihypertensive effects and bioavailability due to higher GABA and pigment content, improving vascular health.

Area of Science:

  • Nutritional Science
  • Pharmacology
  • Cardiovascular Research

Background:

  • Hypertension remains a major global health concern.
  • Natural products are increasingly explored for antihypertensive properties.
  • Red mold rice (RMR) and red mold dioscorea (RMD) are traditional ingredients with potential health benefits.

Purpose of the Study:

  • To investigate the antihypertensive effects of RMR and RMD in spontaneously hypertensive rats (SHRs).
  • To compare the efficacy of RMD and RMR in managing blood pressure.
  • To explore the underlying mechanisms of their effects on vascular health.

Main Methods:

  • Low-dose oral administration of RMR and RMD to SHRs.
  • Monitoring of systolic blood pressure (SBP) and diastolic blood pressure (DBP) after acute and chronic administration.
  • Analysis of vascular elastin structure, gamma-aminobutyric acid (GABA), monascin, ankaflavin, and angiotensin-I-converting enzyme (ACE) inhibitory activity.

Main Results:

  • A single dose of RMD significantly reduced SBP and DBP in SHRs.
  • Chronic administration of RMD and RMR slowed the increase in blood pressure.
  • RMD exhibited a greater antihypertensive effect than RMR, improving vascular elastin remodeling.
  • RMD showed higher GABA, monascin, ankaflavin content, and ACE inhibitory activity compared to RMR.

Conclusions:

  • Red mold dioscorea (RMD) possesses significant antihypertensive properties in spontaneously hypertensive rats.
  • RMD demonstrates superior efficacy over red mold rice (RMR) in lowering blood pressure.
  • The enhanced antihypertensive bioavailability of RMD is attributed to its higher content of GABA, anti-inflammatory pigments, and ACE inhibitory activity.

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