Related Experiment Video
Updated: Jun 22, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Testing Hardy-Weinberg equilibrium using family data from complex surveys
Dewei She1, Hong Zhang, Zhaohai Li
1Department of Statistics, The George Washington University, 2140 Pennsylvania Avenue N.W., Washington, DC 20052, USA.
Abstract:
Genetic data collected during the second phase of the Third National Health and Nutrition Examination Survey (NHANES III) enable us to investigate the association of a wide variety of health factors with regard to genetic variation. The classic question when looking into the genetic variations in a population is whether the population is in the state of Hardy-Weinberg Equilibrium (HWE). Our objective was to develop test procedures using family data from complex surveys such as NHANES III. We developed six Pearson chi(2) based tests for a diallelic locus of autosomal genes. The finite sample properties of the proposed test procedures were evaluated via Monte Carlo simulation studies and the Rao-Scott first order corrected test was recommended. Test procedures were applied to three loci from NHANES III genetic databases, i.e., ADRB2, TGFB1, and VDR. HWE was shown to hold at 0.05 level for all three loci when only families with genotypic information available for two parents and for one or more children were used in the analysis.
Related Concept Videos
Hardy-Weinberg Principle
Evolutionary Relationships through Genome Comparisons
Pedigree Analysis
Genetic Variation
Genes exist in different versions called alleles, which...
Mutation, Gene Flow, and Genetic Drift
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

