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Related Experiment Video

Updated: Jun 22, 2026

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

Published on: March 13, 2014

Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy.

Catrin Furuhjelm¹, Kristina Warstedt, Johanna Larsson

¹Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. catrin.furuhjelm@lio.se

Acta Paediatrica (Oslo, Norway : 1992)

|June 4, 2009

Summary

This summary is machine-generated.

Maternal omega-3 fatty acid supplementation during pregnancy significantly reduced food allergy and eczema in infants with a family history of allergies. This intervention shows promise in preventing early childhood allergic diseases.

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Last Updated: Jun 22, 2026

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

Published on: March 13, 2014

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Area of Science:

Obstetrics and Gynecology
Pediatrics
Immunology

Background:

Maternal intake of omega-3 polyunsaturated fatty acids (PUFAs) has declined, potentially increasing childhood allergy risks.
Allergic diseases in infancy represent a growing public health concern.

Purpose of the Study:

To evaluate the impact of maternal omega-3 long-chain PUFA supplementation during pregnancy and lactation on infant allergic disease incidence.
To assess the efficacy of omega-3 fatty acids in preventing food allergy and IgE-associated eczema.

Main Methods:

A randomized, placebo-controlled trial involving 145 pregnant women with a history of allergies.
Maternal supplementation with 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo from 25 weeks gestation through 3-4 months of breastfeeding.
Infant assessment included skin prick tests, IgE antibody detection, and clinical examinations.

Main Results:

The omega-3 group showed a significantly lower prevalence of food allergy (2% vs. 15%) compared to the placebo group.
Incidence of IgE-associated eczema was also significantly reduced in the omega-3 group (8% vs. 24%).

Conclusions:

Maternal omega-3 fatty acid supplementation appears to decrease the risk of food allergy and IgE-associated eczema in the first year of life.
This intervention is particularly beneficial for infants with a family history of allergic conditions.