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Related Experiment Videos

[Indocyanine green test in the dog].

W Kraft1, J Lechner, A M Vollmar

  • 1I. Medizinischen Tierklinik, Ludwig-Maximilians-Universität München.

Tierarztliche Praxis
|August 1, 1991
PubMed
Summary

The indocyanine green (ICG) test is a safer and more versatile alternative to the less common bromosulfalein (BSP) test for assessing liver function. While more costly, ICG offers valuable insights into liver secretion and circulation.

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Area of Science:

  • Hepatology
  • Clinical Chemistry
  • Diagnostic Imaging

Context:

  • The bromosulfalein (BSP) test, a traditional method for evaluating liver function, is rarely performed due to its limitations.
  • The indocyanine green (ICG) test has emerged as a superior alternative, offering a broader range of applications and fewer adverse effects.
  • Understanding liver function is crucial for diagnosing and managing various hepatic conditions.

Purpose:

  • To evaluate the indocyanine green (ICG) test as a replacement for the bromosulfalein (BSP) test.
  • To compare the efficacy, side effects, and applicability of ICG versus BSP testing.
  • To establish reference values for ICG clearance coefficient and half-life.

Summary:

  • The ICG test is recommended over the BSP test due to fewer side effects and a wider range of use, with minimal extrahepatic influences.
  • Disadvantages of the ICG test include higher costs, specialized equipment, dye solution instability, and a complex calculation procedure.
  • Normal reference values for ICG clearance coefficient range from 0.044 to 0.131 min-1, and for half-life from 5.2 to 11.2 min.
  • The ICG test effectively provides information on overall liver secretion and circulatory status.

Impact:

  • The ICG test offers a more reliable and safer method for assessing liver function compared to the BSP test.
  • This diagnostic tool aids in evaluating the secretory capacity and circulatory dynamics of the entire liver.
  • Clinical adoption of the ICG test can improve diagnostic accuracy and patient outcomes in hepatology.

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