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Related Experiment Video

Updated: Jun 22, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Ceftobiprole: a new beta-lactam antibiotic.

R A Stein¹, R M Goetz, G M Ganea

¹Department of Pathology, New York University School of Medicine, New York, NY, USA. ras2@princeton.edu

International Journal of Clinical Practice

|June 4, 2009

Summary

Ceftobiprole, a new antibiotic effective against MRSA, shows promise for treating skin infections and pneumonia. Clinical trials confirm its non-inferiority to vancomycin, highlighting its potential as a safe and effective therapeutic option.

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Area of Science:

Infectious Diseases
Pharmacology
Clinical Microbiology

Background:

Antimicrobial resistance, particularly methicillin-resistant Staphylococcus aureus (MRSA), poses significant global health challenges.
Developing new antibiotics is time-consuming and costly, necessitating judicious use and extended shelf life of existing and novel agents.
Ceftobiprole, a broad-spectrum beta-lactam antibiotic, has received an approvable letter from the FDA for its activity against MRSA and other pathogens.

Purpose of the Study:

To review clinically relevant findings on ceftobiprole from in vitro studies, animal models, and phase III clinical trials.
To highlight the advantages and limitations of ceftobiprole as a therapeutic option.
To discuss the potential role of ceftobiprole in combating antimicrobial resistance.

Main Methods:

In vitro susceptibility testing against various pathogens.
Efficacy evaluation in animal models of infection.
Analysis of data from completed phase III clinical trials comparing ceftobiprole with standard treatments.

Main Results:

Ceftobiprole exhibits broad-spectrum activity, including against MRSA and other Gram-positive and Gram-negative pathogens.
The antibiotic demonstrates a low propensity for resistance selection and a favorable safety profile.
Phase III trials show ceftobiprole is non-inferior to vancomycin for treating complicated skin and skin structure infections and community-acquired pneumonia.

Conclusions:

Ceftobiprole is a promising parenteral antibiotic for treating serious infections, including those caused by MRSA.
Its efficacy, safety, and favorable resistance profile support its role in clinical practice.
Further understanding and judicious use of ceftobiprole are crucial in addressing antimicrobial resistance.