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Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

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Published on: August 2, 2022

Nonenhancing brain metastases.

Sasan Karimi¹, Eric Lis, Saba Gilani

¹Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. karimis@mskcc.org

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging

|June 4, 2009

Summary

Brain metastases from lung cancer typically show contrast enhancement on imaging. This case highlights a rare instance where bevacizumab (Avastin) treatment may have caused a lack of enhancement in these lesions.

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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

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Published on: June 7, 2020

Area of Science:

Neuro-oncology
Radiology
Medical Oncology

Background:

Metastatic brain disease is a common complication of lung cancer.
Radiological evaluation of brain metastases typically involves contrast-enhanced magnetic resonance imaging (MRI).
Multiple enhancing lesions are the characteristic finding in metastatic brain disease.

Observation:

A case of metastatic lung cancer to the brain was observed.
The brain metastases in this patient did not show contrast enhancement.
The patient had received bevacizumab (Avastin), an antiangiogenic agent, prior to imaging.

Findings:

The absence of contrast enhancement in brain metastases is unusual.
Bevacizumab (Avastin) targets vascular endothelial growth factor (VEGF), inhibiting angiogenesis.
The antiangiogenic effect of bevacizumab may have reduced vascularity and contrast uptake in the metastases.

Implications:

This case suggests that antiangiogenic therapy can alter the radiological appearance of brain metastases.
Radiologists and oncologists should consider prior antiangiogenic treatment when interpreting brain imaging in cancer patients.
Further research is needed to understand the full impact of antiangiogenic agents on the imaging characteristics of brain metastases.