Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of systemic steroids on asthma biomarkers: A comprehensive analysis.

The World Allergy Organization journal·2026
Same author

Response to the comment regarding our article entitled "A 300 IR 5-grass pollen sublingual immunotherapy tablet-specific systematic review and meta-analysis confirms its clinical benefits for patients with allergic rhinoconjunctivitis with or without asthma".

The World Allergy Organization journal·2026
Same author

Development and Validation of the Risk of Exacerbation in Severe Asthma (RESA) Model.

The journal of allergy and clinical immunology. In practice·2026
Same author

What is new on the horizon for the biologics world: New kids of the block - WAO state of art.

The World Allergy Organization journal·2026
Same author

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies.

Clinical and translational allergy·2026
Same author

Longitudinal observation of severe asthma comorbidities and oral corticosteroids use from SANI and ISAR registries.

The World Allergy Organization journal·2026

Related Experiment Video

Updated: Jun 22, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

When allergic rhinitis is not only allergic.

Matteo Gelardi1, Cosimo Russo, Maria Luisa Fiorella

  • 1Department of Otolaryngology II, University of Bari, Bari, Italy.

American Journal of Rhinology & Allergy
|June 4, 2009
PubMed
Summary
This summary is machine-generated.

Approximately 12% of patients with allergic rhinitis (AR) exhibit atypical symptoms due to non-allergic inflammation. Nasal cytology aids in identifying these distinct AR forms, which often present with increased eosinophils and mast cells.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Related Experiment Videos

Last Updated: Jun 22, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Area of Science:

  • Allergy and Immunology
  • Otorhinolaryngology
  • Cellular Biology

Background:

  • Seasonal allergic rhinitis (AR) patients sometimes experience persistent symptoms despite minimal allergen exposure.
  • Atypical AR forms may involve mechanisms beyond typical allergen triggers.
  • Understanding these atypical cases is crucial for effective clinical management.

Purpose of the Study:

  • To investigate the clinical and cytological features of atypical allergic rhinitis (AR).
  • To differentiate atypical AR from typical presentations.
  • To identify potential underlying inflammatory mechanisms in persistent AR.

Main Methods:

  • Studied 519 patients with AR and positive skin tests to pollens.
  • Assessed symptom duration, correlation with sensitization, and reactivity to nonspecific stimuli.
  • Performed rhinoscopy and nasal scraping for cytological analysis.

Main Results:

  • Identified 60 patients (11.5%) with atypical/mixed rhinitis, showing symptoms independent of allergen exposure and triggered by nonspecific stimuli.
  • Atypical AR cases exhibited significantly higher levels of nasal eosinophils and mast cells out of season (p < 0.05).
  • These patients more frequently had co-existing asthma and eosinophilic polyps.

Conclusions:

  • Atypical inflammatory mechanisms appear to influence approximately 12% of AR patients.
  • Nasal cytology is a valuable tool for distinguishing these atypical AR forms.
  • Findings suggest a distinct inflammatory profile in a subset of AR patients.