Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure and Function of Leukocytes

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chih Tu: a pioneer of Xinjiang's agricultural science.

Protein & cell·2014

Same author

National trends and disparities in cervical cancer screening among commercially insured Women, 2001-2010.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2014

Same author

Persistent medication affordability problems among disabled Medicare beneficiaries after Part D, 2006-2011.

Medical care·2014

Same author

Characterizing topological patterns in amnestic mild cognitive impairment by quantitative water diffusivity.

Journal of Alzheimer's disease : JAD·2014

Same author

Access to affordable medicines after health reform: evidence from two cross-sectional surveys in Shaanxi Province, western China.

The Lancet. Global health·2014

Same author

Increased acyl ghrelin but decreased total ghrelin and unacyl ghrelin in Chinese Han people with impaired fasting glucose combined with impaired glucose tolerance.

Peptides·2014

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

Effect of taurine on leucocyte function.

Lei Wang¹, Na Zhao, Fang Zhang

¹Department of Pharmacy, Medical College of Qingdao University, Qingdao, Shandong Province, China. qingdaowl@yeah.net

European Journal of Pharmacology

|June 4, 2009

Summary

This summary is machine-generated.

Taurine supplementation enhances white blood cell function following cyclophosphamide chemotherapy. This study shows taurine improves immune cell counts and activity, aiding recovery from chemotherapy-induced immunosuppression.

More Related Videos

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

Published on: November 1, 2013

Related Experiment Videos

Last Updated: Jun 22, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

Published on: November 1, 2013

Area of Science:

Immunology
Pharmacology
Oncology

Background:

Antitumor drugs like cyclophosphamide can cause adverse effects, including bone marrow and immune system damage.
Ancillary drugs are needed to enhance chemotherapy efficacy and mitigate side effects.
Leukocyte function is crucial for immune response and recovery during cancer treatment.

Purpose of the Study:

To investigate the potential of taurine as an ancillary drug to enhance leukocyte function after cyclophosphamide chemotherapy.
To evaluate taurine's impact on immune system recovery in a Lewis lung carcinoma mouse model.

Main Methods:

Lewis lung carcinoma-bearing mice were treated with cyclophosphamide alone or in combination with varying doses of taurine.
Key indicators assessed included tumor inhibition rate, bone marrow nucleate cell count, white blood cell counts and classification, spleen and thymus indices, lymphocyte proliferation, and phagocytic activity of macrophages.
Peripheral blood neutrophilic granulocyte and monocyte counts were also analyzed.

Main Results:

Taurine, in combination with cyclophosphamide, demonstrated higher tumor inhibition rates compared to cyclophosphamide alone.
Significant increases were observed in bone marrow nucleate cell counts, white blood cell counts and classification, spleen and thymus indices, lymphocyte proliferation, and phagocytic activity across all taurine dosage groups.
Peripheral blood neutrophilic granulocyte and monocyte levels were also elevated.

Conclusions:

Taurine effectively enhances leukocyte function following cyclophosphamide chemotherapy.
Taurine shows promise as an adjunctive therapy to support immune recovery during cancer treatment.
The findings suggest taurine can attenuate chemotherapy-induced immunosuppression and improve immune system resilience.