Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

The Spinal Cord

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.

Spinal Cord: Cross-sectional Anatomy

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...

Herniated Intervertebral Disc l: Introduction

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

Spinal Cord: Gross Anatomy

Spinal Cord: Gross Anatomy

The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...

Spinal Cord

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

Epilepsia·2026

Same author

High-frequency oscillations after acute hemorrhagic traumatic brain injury: insights into posttraumatic epilepsy development.

Epilepsia·2026

Same author

Digital twins. The future of personalized epilepsy care.

Epilepsy & behavior : E&B·2026

Same author

Video-based diagnostics supported by artificial intelligence as an opportunity to address the epilepsy diagnostic gap: A narrative review.

Epilepsia·2026

Same author

A two-stage algorithm to detect electrographically focal seizures using a wearable single-channel EEG sensor.

IEEE transactions on bio-medical engineering·2026

Same author

Evaluating multimodal autonomic correlations in pediatric epilepsy using wearable biosignals.

Epilepsia·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Holocord spinal epidural abscess.

Partha Sekhar Ghosh¹, Tobias Loddenkemper, Manuel Buitrago Blanco

¹Pediatric Hospital Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. ghoshp3@ccf.org

Journal of Child Neurology

|June 4, 2009

Summary

This summary is machine-generated.

A rare holocord epidural abscess in an infant, caused by MRSA, was successfully treated with antibiotics alone. This case highlights a conservative approach for extensive spinal epidural abscesses in children, avoiding surgery and preventing neurological deficits.

More Related Videos

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

Related Experiment Videos

Last Updated: Jun 22, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

Area of Science:

Pediatric Infectious Diseases
Pediatric Neurology
Neurosurgery

Background:

Spinal epidural abscess (SEA) is uncommon in infants, often leading to severe neurological impairment if untreated.
Holocord epidural abscess, affecting the entire spinal cord, is exceptionally rare, particularly in pediatric populations.
Methicillin-resistant Staphylococcus aureus (MRSA) septicemia can manifest with diverse complications, including abscess formation.

Purpose of the Study:

To report an extremely rare case of holocord spinal epidural abscess in an infant.
To describe the successful conservative management of this extensive pediatric SEA.
To emphasize the potential for non-surgical treatment in select cases of infant spinal epidural abscess.

Main Methods:

A 7-month-old infant with MRSA septicemia presented with symptoms suggestive of spinal cord compression.
Magnetic resonance imaging (MRI) confirmed an extensive epidural abscess spanning from the cervical to the lumbar spine.
The patient was treated conservatively with a 6-week course of intravenous antibiotics.

Main Results:

The infant presented with fever, irritability, tachypnea, and decreased limb movement.
MRI revealed a holocord epidural abscess without associated osteomyelitis or discitis.
Following 6 weeks of antibiotic therapy, the patient showed complete neurological recovery at 3-month follow-up.

Conclusions:

Conservative management with intravenous antibiotics can be effective for holocord spinal epidural abscess in infants.
Early diagnosis and prompt treatment are crucial to prevent permanent neurological deficits.
This case adds to the limited literature on holocord SEA in children, supporting a non-surgical approach in select cases.